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In the capecitabine arm, patients are administered oral capecitabine at a dose of 1,000 mg m 2 bid for 2 weeks on 1 week off for 12 weeks, while in the standard chemotherapy arm, patients are administered either oral cyclophosphamide at a dose of 100 mg m 2 on days 1 14, parenteral methotrexate at a dose of 40 mg m 2 on days 1 and 8, and parenteral 5-fu at a dose of 600 mg m 2 on days 1 and 8 of 4-week cycles or parenteral doxorubicin at a dose of 60 mg m 2 on day 1 and cyclophosphamide at a dose of 600 mg m 2 on day 1 of 3-week cycles for a duration of 12 weeks fig.
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