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Co-administration of a single 500 mg oral dose of lariam with 400 mg of ketoconazole once daily for 10 days in 8 healthy volunteers resulted in an increase in the mean c max and auc of lariam by 64 and 79 , respectively, and an increase in the mean elimination half-life of lariam from 322 hours to 448 hours.
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The benefits of lariam therapy should be weighed against the possibility of adverse effects in patients with cardiac disease.
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Note to the minister it was particularly unhelpful when the mod published its first 10-page statistical bulletin on lariam on the day we took evidence from the minister.
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when prophylaxis with lariam fails, physicians should carefully evaluate which antimalarial to use for therapy.
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